How is insulin dosage determined?

（1）Determine the daily dose

Type 1 diabetes mellitus：0.5 ～ 1 U/kg/d；

Type 2 diabetes mellitus：0.3 ～ 0.8 U/kg/d.

Generally, the lowest dose is started, but in patients with higher body weight or severe insulin resistance, the median value can be started.

（2）Determine the basal/mealtime dose ratio

The basal insulin dose ratio is determined based on the total daily insulin amount, usually a 50/50 ratio, but this varies from person to person, with some people requiring a 40/60 ratio.

（3）Determine the amount of each injection

1.Patients who receive short-acting insulin injections 3 times a day.

It is allocated according to the method of "dividing the total amount of meals by 3, minus 2 plus breakfast" (i.e. before breakfast> before dinner> before lunch). For example, if you take 30 units of short-acting insulin daily, divide by 3 equals 10 units, subtract 2 units from noon, and add it in the morning, i.e., 12 units in the morning, 8 units at noon, and 10 units in the evening.

2.Patients who receive 2 injections of premixed insulin per day

2/3 of the total amount of injections before breakfast and 1/3 of the total amount of injections before dinner.

3. When basal insulin is chosen in combination with oral medications

If long-acting insulin is used, the starting dose is 0.1 ~ 0.2 U/kg/d, but in patients with obesity or HbA1c > 8.0%, 0.2 ~ 0.3 U/kg/d can be considered as the starting dose and injected once a day at bedtime;

If intermediate-acting insulin is used, the recommended starting dose is 0.1 ~ 0.2 U/kg/d or 10 U/d, injected once a day at bedtime or twice a day (before breakfast and before bedtime).

The information is from the Internet and is for reference only.