Pen Injector：

As a new way for patients to self-administer medication, pen syringes have many advantages such as ease of use, reduction of drug waste, and lowering the difficulty of patients to self-administer medication, and they have a wide range of application prospects in patient self-administration of medication.

Components of pen injectors, advantages, concerns, and scenarios of use take a closer look at pen injectors as a new way to self-administer medications.

Pen injector is a new type of portable medical equipment, pen injector shape with it like a commonly used writing pen, through the manual pump to push the liquid for injection. Pen injectors are commonly used for insulin medication for diabetic patients. Before the introduction of pen injector, patients needed to use injector to remove medication from ampoules or vials for injector, and for patients who need to inject medication frequently, this injection method seriously affects the patients' daily work and life, and pen injectors are very convenient for patients to use medication on their own.

Composition of pen injectors:

The pen injector mainly consists of a pen cap, a refill holder, a refill (rubber mold, refill tube, rubber piston), a pen body (mechanical devices: piston rod, dosage display, dosage adjustment, injection pushbutton), and a needle (outer needle cap, inner needle cap, needle tip, protective sheet).

1. Pen cap

Pen cap: The pen cap is used to protect the pen core and mechanical devices, not in direct contact with the liquid, the material is usually PC/ABS (by (PC) and (ABS) merged into a thermoplastic plastic material), with good mechanical properties and chemical inertia.

2. Refill holder

Refill holder：Refill holders are used to mount and protect the refills from direct contact with the liquid, and are also commonly made of PC/ABS.

3.Refill

The refill consists of a rubber membrane, a refill tube, and a rubber piston, which is the system for storing the medication solution, and is in direct contact with the medication solution, and needs to have good compatibility and sealing.

The refill usually stores the liquid used many times, the rubber membrane may be pierced by the needle many times, the rubber membrane needs to have good self-sealing (pierced by the needle many times and keep good self-sealing), the piercing debris should also comply with the relevant regulations. Refill tubes are usually cassette bottles, usually made of medium or high borosilicate glass, which has a good coefficient of expansion, water resistance, and physical and chemical stability to ensure the storage stability of the liquid.

The rubber piston is usually made of halobutyl rubber. The piston is in direct contact with the drug solution and needs to have good compatibility and sealing with the drug solution. The pen injector delivers the drug by quantitatively pushing the rubber piston, which slides inside the barrel of the pen cartridge and requires a suitable actuating force.

4. Pen Body

The pen body is the core mechanical device of the pen injector, mainly including the piston rod, dose display, dose adjustment, injection push button and other parts, through the precise cooperation of these mechanical devices to achieve the purpose of accurate drug delivery.

5. Needle

Needle includes outer needle cap, inner needle cap, needle, protective sheet, needle is usually made of stainless steel, need to have excellent sharpness and rigidity.

How to use the pen Injector:

1.Open the package of the pen injector, take out the pen injector, check whether it is intact.

2. Take out the pen injector, check whether it is intact, confirm the name of the drug and the dose, load the pen injector, and then sterilize the rubber membrane at the front end of the pen injector with 75% alcohol (it needs to be sterilized before each use, and the pen injector is usually replaced after use).

3. Install the needle, stand the pen up so that the air bubbles in the refill collect in the upper part, exhaust the air bubbles in the refill until a drop of liquid is discharged.

4. Sterilize the injection site with 75% alcohol, pinch up the skin of the site with your left hand, hold the injection pen with your right hand, quickly insert the needle vertically, press the injection key with your right thumb to push the injection solution slowly and evenly, stay for about 10 seconds after the injection and then pull out the needle quickly in the direction of the needle insertion, and use a cotton swab to press down on the eye of the needle.

5. Cover the needle cap, collect the needles and bring them to the hospital for centralized disposal. Put the pen Injector back into the box for collection.

Advantages of pen injector:

1. Convenient to use

Pen injectors can be injected directly after just replacing the needle, which is very convenient for clinical use and suitable for patients who need to inject drugs for a long time on their own.

2. Prevent contamination

Pen injector eliminates the traditional step of using a injector to remove the liquid from the injection bottle, reducing cross-contamination and secondary pollution in the injection process.

3. Reduction of drug wastage

Pen injectors are suitable for multi-dose medications and can effectively avoid drug wastage.

4.Precise dosage delivery

Pen injectors are used to adjust the dosage of medication through precise mechanical adjustment, which is more accurate than the manual extraction of medication by healthcare professionals.

Pen Injector Concerns

1. Compatibility

The part of the pen injector in contact with the liquid is the pen core and the pen tip.

Among them, the pen tip is a one-off single use, usually made of stainless steel, inert in nature, chemically stable, and low risk of compatibility with the drug solution.

Refill by the rubber membrane, refill tube, rubber piston composition, rubber membrane and rubber piston is usually rubber material, rubber material has good elasticity and sealing, but the composition of the material is also more complex. Refill tube is usually borosilicate glass material, borosilicate glass material has a good coefficient of expansion, water resistance and physical and chemical stability, but the composition of the material is also more complex. Due to the complexity of the composition of the refill, and the high risk of compatibility with the drug solution, need to do a series of compatibility studies such as extraction, migration, elements, adsorption.

2. Sealing

The pen injector is sealed by the rubber membrane and rubber piston at both ends of the pen cartridge tube, and if the drug specification is a multi-dose package, the requirements for sealing will be more stringent. If the sealing is not good, it will lead to the entry of gas, or lead to the loss of contents and microbial invasion, which will seriously affect the safety and effectiveness of drugs.

Manufacturing enterprises need to use high-voltage electric leakage detection and other inspection methods for the sealing of the full inspection of the drug, do not have the conditions of the full inspection of the production enterprises also need to carry out random testing of the sealing of the drug, can not rely solely on the finished product of the sterility of the sealing of the drug on behalf of the drug.

3. Starting force sliding force

Starting force sliding force affects the clinical use of the pen injector, too much starting force sliding force may lead to difficulties in clinical use, too little starting force may lead to free movement of the rubber piston in the cartridge tube, thus affecting the sealing of the pen injector.

Application Scenarios for Pen Injectors

Patient self-administration, pen syringes are very convenient for patients to self-administer their medications, which is particularly suitable for multi-dose packaged preparations, greatly reducing the number of hospital admissions and having less impact on the patient's work and life

Summary:

As a new way for patients to self-administer drugs, pen injectors have significant advantages over traditional drug delivery methods. With the continuous improvement of health care and the diversified development of the application scenarios of pen injectors, pen injectors are also bound to have a broader application prospect in the future.

The information is from the Internet and is for reference only.