Insulin and semaglutide are both injectable hypoglycemic drugs，the difference between the two drugs is:

The mechanism of lowering glucose is different

Insulin is a long-acting human insulin analogue made by modifying the chemical structure of human insulin, which has a direct hypoglycemic effect, which is different from the hypoglycemic mechanism of insulin.

Semaglutide belongs to GLP-1 (glucagon-like peptide-1) receptor agonist hypoglycemic drugs, GLP-1 is a substance secreted by human intestinal mucosal cells, this substance can intelligently promote insulin secretion according to the change of blood glucose concentration in the body, semaglutide belongs to GLP-1 (glucagon-like peptide-1) receptor agonist hypoglycemic drugs, GLP-1 is a substance secreted by human intestinal mucosal cells, this substance can intelligently promote insulin secretion according to the change of blood glucose concentration in the body, Semaglutide stimulates insulin secretion when the blood glucose concentration is high, and semaglutide plays a hypoglycemic role by mimicking the natural GLP-1 and activating the GLP-1 receptor, so hypoglycemia rarely occurs when this type of drug is used alone.

The scope of clinical application is not the same

As a long-acting insulin analogue, insulin is mainly used for hypoglycemic therapy, while semaglutide, as a GLP-1 receptor agonist, has the effect of weight loss, blood pressure reduction, improvement of blood lipid profile, heart and kidney protection, and can be used as a preferred variety for patients with type 2 diabetes who have cardiovascular diseases such as coronary heart disease and chronic kidney disease.

Usage

As basal insulin, it should be injected at the same time every day, while semaglutide, as a long-acting formulation in GLP-1 receptor agonists, only needs to be injected once a week, greatly simplifying the medication procedure and providing strong patient compliance.

Suitable for

Insulin is a treatment for both type 1 and type 2 diabetes, while semaglutide is only used to treat type 2 diabetes.

In addition, patients must use semaglutide and insulin under the guidance of a specialist to avoid the harm caused by drug side effects.

The information is from the Internet and is for reference only.